1,3,4-Oxadiazole formation; a novel solid support strategy

A new approach to the synthesis of 1,3,4-oxadiazoles on solid support is described. Resin bound 1-acyl thiosemicarbazides were treated with a variety of dehydrating agents at different temperatures, which revealed that thiosemicarbazides were effectively cyclised by 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC·HCl); mild acidic cleavage from the solid support released the substituted 1,3,4-oxadiazoles in excellent purity.