Title of article :
A regioselective PCl5 mediated dehydration for preparing Δ9,11 corticosteroids
Author/Authors :
Fu، نويسنده , , Xiaoyong and Tann، نويسنده , , Chou-Hong and Thiruvengadam، نويسنده , , Kathy T.K. and Lee، نويسنده , , Junning and Colon، نويسنده , , Cesar، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
A regioselective PCl5-induced dehydration of 11α-hydroxy corticosteroids was invented to provide the corresponding Δ9,11 double bond trienes in excellent yield (>90%) with 99:1 regioisomeric ratio to the Δ11,12 isomers. A syn-elimination mechanism was proposed for this reaction.
Keywords :
dehydration , Corticosteroids , Betamethasone , mometasone , phosphorous pentachloride , syn-elimination
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
