Title of article
Immunosensor for the determination of azidothymidine: Its utilization as detector in a sequential injection analysis system
Author/Authors
Stefan، نويسنده , , Raluca-Ioana and Bokretsion، نويسنده , , Rahel Girmai and van Staden، نويسنده , , Jacobus Frederick and Aboul-Enein، نويسنده , , Hassan Y، نويسنده ,
Issue Information
ماهنامه با شماره پیاپی سال 2003
Pages
5
From page
883
To page
887
Abstract
An amperometric immunosensor based on graphite paste (graphite powder and paraffin oil) has been constructed for the assay of azidothymidine (AZT). The graphite paste is impregnated with anti-AZT. The immunosensor can be reliably used for the assay of AZT in its pharmaceutical formulation. The potential used for AZT assay was 435 mV vs Ag/AgCl electrode. The surface of the immunosensor can be regenerated by simply polishing, obtaining fresh immunocomposite ready to be used in a new assay. Due to its reliability, the immunosensor was successfully used as a detector in a sequential injection analysis system, and gave reliable results for on-line assay of AZT purity in raw material and AZT contents in pharmaceutical formulations.
Keywords
Amperometric immunosensor , Zidovudine , Sequential injection analysis , Azidothymidine
Journal title
Talanta
Serial Year
2003
Journal title
Talanta
Record number
1644330
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