Title of article
Stereoselective synthesis of an isoprostane synthon via 8,12-free-radical cyclization
Author/Authors
Mulzer، نويسنده , , Johann and Czybowski، نويسنده , , Michael and Bats، نويسنده , , Jan-W، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
2961
To page
2964
Abstract
Aiming at a stereocontrolled biomimetic synthesis of isoprostanes a fully stereocontrolled 8,12-free radical cyclization has been achieved via intermediate 10 by annulating an endocyclic radical to a butenolide acceptor double bond. In this way ent-12-epi-PGF2α (ent-2) can be prepared.
Keywords
free radical cyclization , Biomimetic synthesis , isoprostanoids
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1644390
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