The utilization of copper(II) phosphate for the anodic stripping voltammetric assay of alendronate sodium, desferrioxamine mesylate and lisinopril

A sensitive differential pulse anodic stripping voltammetric method is described for the determination of alendronate sodium, desferrioxamine mesylate and lisinopril. The procedure is based on the formation of labile drug–copper(II) complex when shaking with copper(II) phosphate suspension. The voltammetric peaks, which correspond to the reduction of the copper(II) moiety of the formed complexes are obtained at −153, −74 and −111 mV, respectively. The different experimental parameters have been carefully studied. The method has been fully validated. The limit of detection was as low as 8.6 ng ml−1. The method has been applied successfully for the determination of the drugs in plasma and in their pharmaceutical preparations. The obtained results were compared statistically with those obtained from a published method, in case of AS, or the official USP methods, for the other two drugs.