O-Silyl triflate-promoted addition of diethyl phosphite to chiral aldonitrones. A rapid access to complex α-amino phosphonates and their N-hydroxy derivatives

The addition reaction of diethyl phosphite to O-silylated N-benzyl nitrones derived from chiral α-alkoxy and N-Boc α-amino aldehydes has been studied as a stereoselective carbonphosphorus bond forming process for the synthesis of polyhydroxylated α-amino and α,β-diamino phosphonates. Key intermediates are the corresponding N-hydroxy α-amino phosphonates.