Title of article :
Structure of a novel multidrug resistance modulator, irciniasulfonic acid, isolated from a marine sponge, Ircinia sp.
Author/Authors :
Kawakami، نويسنده , , Ayako and Miyamoto، نويسنده , , Tomofumi and Higuchi، نويسنده , , Ryuichi and Uchiumi، نويسنده , , Takeshi and Kuwano، نويسنده , , Michihiko and Van Soest، نويسنده , , Rob W.M. van Soest، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
Irciniasulfonic acid was obtained from a marine sponge of Ircinia sp. Spectroscopic and chemical analyses revealed its structure consists of three different kinds of acids, i.e. common fatty acids, a novel unsaturated branched C-10 fatty acid and an isethionic acid. Irciniasulfonic acid and deacyl irciniasulfonic acid reverse multidrug resistance in human carcinoma cells caused by overexpression of membrane glycoprotein.
Keywords :
Multidrug resistance , Ircinia sp. , irciniasulfonic acid , sulfonic acids and derivatives
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
