Author/Authors :
Fort، نويسنده , , Sébastien and Coutinho، نويسنده , , Pedro M and Schülein، نويسنده , , Martin and Nardin، نويسنده , , Robert and Cottaz، نويسنده , , Sylvain and Driguez، نويسنده , , Hugues، نويسنده ,
Abstract :
This paper reports the rational design, synthesis and biochemical evaluation of a new type of cellulase inhibitor. This isofagomine isomer analogous to the β-l-idopyranose linked to a glucosidic unit by a methylenic bond is able to mimic the pseudo-axial orientation of the ‘aglycon’ observed in the X-ray structure of a non-hydrolyzable thiooligosaccharide/cellulase complex.
