Synthesis of α-(heteroarylthio)-α,α-difluoroacetophenone derivatives via the SRN1 methodology

New α-(heteroarylthio)-α,α-difluoroacetophenone Ar1-COCF2S-Ar2 derivatives 8–15 were synthesized in moderate to good yields via the SRN1 methodology, from the reaction of a series of chlorodifluoromethylated ketones 1–4 with aromatic and heterocyclic thiols 5–7. The corresponding Ar1-CHOHCF2S-Ar2 16–23 were also prepared in moderate yields, using sodium borohydride in absolute ethanol. The compounds may find some biological applications as potent anti-HIV-1 as well as useful synthons for agrochemicals.