Title of article :
A convenient synthesis of N-Fmoc-N,N′-bis-Boc-7-guanyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (Fmoc-N,N′-bis-Boc-7-guanyl-Tic-OH, GTIC)
Author/Authors :
Santagada، نويسنده , , Vincenzo and Fiorino، نويسنده , , Ferdinando and Severino، نويسنده , , Beatrice and Salvadori، نويسنده , , Severo and Lazarus، نويسنده , , Lawrence H and Bryant، نويسنده , , Sharon D and Caliendo، نويسنده , , Giuseppe، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
Fmoc-N,N′-Bis-Boc-7-guanyl-Tic-OH (GTIC), a conformationally constrained amino acid with basic properties, has been synthesized in four steps. This amino acid can be incorporated into peptides using standard Fmoc solid phase synthesis, and to test its potential for biological activity applications, we prepared an analog of H-Dmt-Tic-NH2.
Keywords :
unconventional amino acid , Synthesis , GTIC
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
