• Title of article

    Isolation and structure elucidation of two novel deformylase inhibitors produced by Streptomyces sp.

  • Author/Authors

    Chu، نويسنده , , Min and Mierzwa، نويسنده , , Ronald and He، نويسنده , , Ling and Xu، نويسنده , , Ling and Gentile، نويسنده , , Frank and Terracciano، نويسنده , , Joseph and Patel، نويسنده , , Mahesh and Miesel، نويسنده , , Lynn and Bohanon، نويسنده , , Samantha and Kravec، نويسنده , , Cynthia and Cramer، نويسنده , , Christina and Fischman، نويسنده , , Thierry O and Hruza، نويسنده , , Alan and Ramanathan، نويسنده , , Lata and Shipkova، نويسنده , , Petia and Chan، نويسنده , , Tze-Ming، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2001
  • Pages
    3
  • From page
    3549
  • To page
    3551
  • Abstract
    Sch 382582 (1) and Sch 382583 (2), two novel pseudopeptides, were isolated from fermentation broth of Streptomyces sp. as bacteria peptide deformylase inhibitors. Structure elucidation of 1 and 2 was accomplished by extensive 2D NMR spectroscopic studies including NOESY, HMQC-TOCSY and HMBC experiments, and the relative stereochemistry was determined by X-ray crystallography. Both compounds displayed potent inhibitory activity against E. coli deformylase.
  • Keywords
    novel pseudopeptides , 1H and 13C NMR data , Purification , Structure elucidation
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2001
  • Journal title
    Tetrahedron Letters
  • Record number

    1644866

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1644866