Title of article :
Polarography and artificial neural network for the simultaneous determination of nalidixic acid and its main metabolite (7-hydroxymethylnalidixic acid)
Author/Authors :
Guiberteau، نويسنده , , Agustina and D??az، نويسنده , , Teresa Galeano and Rodr??guez C?ceres، نويسنده , , Mar??a I. and Ortiz Burguillos، نويسنده , , Juan M. and Mer?s، نويسنده , , Isabel Dur?n and L?pez، نويسنده , , Francisco Salinas Lopez، نويسنده ,
Issue Information :
ماهنامه با شماره پیاپی سال 2004
Abstract :
Nalidixic acid (NA) and its main metabolite, 7-hydroxymethylnalidixic acid (OH-NA), are simultaneously determined by applying artificial neural networks (ANNs), to their square wave voltammetric signals. The scores of a PCR model, built with the voltammetric data of a set of standard samples, recorded between −0.70 and −1.0 V, are used as training set for the net for each compound. The trained nets (ANNs) are used for the simultaneous determination of NA and OH-NA in urine. The recovery values are comprised between 91 and 109% for NA and between 82 and 112% for OH-NA, being these results better than the results obtained by application of partial least squares (PLS) multivariate calibration.
Keywords :
Nalidixic Acid , Artificial Neural Networks (ANN) , 7-Hydroxymethylnalidixic acid , Square Wave Voltammetry
