Catalytic enantioselective direct Michael additions of ketones to alkylidene malonates
Author/Authors :
Betancort، نويسنده , , Juan M and Sakthivel، نويسنده , , Kandasamy and Thayumanavan، نويسنده , , Rajeswari and Barbas III، نويسنده , , Carlos F، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Pages :
4
From page :
4441
To page :
4444
Abstract :
Enantioselective direct Michael additions of ketones using (S)-1-(2-pyrrolidinylmethyl)-pyrrolidine as a catalyst are described. Michael adducts with up to 91% e.e. were obtained by the reaction of alkylidene malonates with simple unactivated ketones under mild reaction conditions.
Keywords :
asymmetric catalyst , Michael reaction , asymmetric synthesis
