Title of article :
Diethyl oxomalonate as a three carbon synthon for synthesis of functionalized 1,1′-disubstituted tetrahydroisoquinoline
Author/Authors :
Bois-Choussy، نويسنده , , Michèle and Cadet، نويسنده , , Sébastien and De Paolis، نويسنده , , Michael X. Zhu، نويسنده , , Jieping، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
Pictet–Spengler condensation of β-arylethylamine with diethyl oxomalonate provides an entry to highly functionalized 1,1′-disubstituted tetrahydroisoquinoline in high yield. Selective functionalization of two ester groups is demonstrated.
Keywords :
1?-disubstituted tetrahydroisoquinoline , 1 , quaternary carbon , Pictet–Spengler reaction , diethyl oxomalonate , conformationally constrained amino acid
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
