Title of article
Synthesis of (2S,3S)-β-methyltryptophan
Author/Authors
Han، نويسنده , , Guoxia and Lewis، نويسنده , , Arwel and Hruby، نويسنده , , Victor J، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
4601
To page
4603
Abstract
Nα-Fmoc-protected (2S,3S)-β-methyltryptophan has been synthesized by asymmetric synthesis through the aid of an oxazolidinone auxiliary. Coupling of the mixed anhydride of Nin-Boc-protected indoleacrylic acid to the oxazolidinone auxiliary was achieved by lithium bromide and N,N-dimethylpyridine (DMAP). This reaction is milder and more convenient to run than the traditional conditions using butyl lithium.
Keywords
auxiliary assisted asymmetric synthesis , constrained amino acids , lithium bromide (LiBr) , N , ?-methyltryptophan , N-dimethylaminopyridine (DMAP)
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1645680
Link To Document