Title of article :
(2R,3S,5S)-2-Acetoxy-3-fluoro-5-(p-toluoyloxymethyl)tetrahydrofuran: a key intermediate for the practical synthesis of 9-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl)adenine (FddA)
Author/Authors :
Jin، نويسنده , , Fuqiang and Wang، نويسنده , , Dengjin and Confalone، نويسنده , , Pat N. and Pierce، نويسنده , , Michael E. and Wang، نويسنده , , Zhe and Xu، نويسنده , , Guoyou and Choudhury، نويسنده , , Anusuya and Nguyen، نويسنده , , Dieu، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
A highly efficient synthesis of (2R,3S,5S)-2-acetoxy-3-fluoro-5-(p-toluoyloxymethyl)tetrahydrofuran (2a) was developed. As a key intermediate, 2a was effectively applied to the synthesis of 9-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl)adenine (FddA), thus, providing a practical synthetic approach to FddA.
Keywords :
nucleosides , Lactones , purines , coupling reactions
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
