Title of article
A convergent synthesis of the renin inhibitor SPP-100 using a nitrone intermediate
Author/Authors
Dondoni، نويسنده , , Alessandro and De Lathauwer، نويسنده , , Geert and Perrone، نويسنده , , Daniela، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
5
From page
4819
To page
4823
Abstract
The total synthesis of SPP-100 and its C-5 epimer involves the construction of the β-amino alcohol segment via addition of the Grignard reagent derived from 3-aryl-2-isopropyl-1-chloropropane to the nitrone functional group installed at C-4 of the pseudoephedrine spiroanellated γ-butyrolactone derivative.
Keywords
Nitrones , amination , Dipeptide isostere , renin inhibitor
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1645849
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