Title of article :
A convergent synthesis of the renin inhibitor SPP-100 using a nitrone intermediate
Author/Authors :
Dondoni، نويسنده , , Alessandro and De Lathauwer، نويسنده , , Geert and Perrone، نويسنده , , Daniela، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
The total synthesis of SPP-100 and its C-5 epimer involves the construction of the β-amino alcohol segment via addition of the Grignard reagent derived from 3-aryl-2-isopropyl-1-chloropropane to the nitrone functional group installed at C-4 of the pseudoephedrine spiroanellated γ-butyrolactone derivative.
Keywords :
Nitrones , amination , Dipeptide isostere , renin inhibitor
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
