An approach towards the C1–C16 fragment of antineoplastic macrolide bryostatins by kinetic resolution of a racemic terminal epoxide using Jacobsenʹs catalyst

A stereo- and enantioselective approach towards the C1–C16 fragment of bryostatins is reported using Jacobsenʹs catalyst for kinetic resolution of a terminal epoxide, a Horner–Wadsworth–Emmons coupling reaction and a 1,4-Michael type cyclization as key steps.