Author/Authors :
Garc??a Mart??nez، نويسنده , , Antonio and Teso Vilar، نويسنده , , Enrique and Garc??a Fraile، نويسنده , , Amelia and de la Moya Cerero، نويسنده , , Santiago and Lora Maroto، نويسنده , , Beatriz، نويسنده ,
Abstract :
The enantiospecific preparation of two novel C10-S(II)- and C10-Se(II)-substituted camphor derivatives (arylsulfide and arylselenide) from readily available camphor is described. The established three-step route constitutes a model procedure for the straightforward preparation of interesting enantiopure C10-S- and C10-Se-substituted camphor-derived chiral sources. The key-step of the described route is an enantiospecific Wagner–Meerwein rearrangement of 3,3-dimethyl-2-methylenenorbornan-1-ol 6 under electrophilic treatment with an arylsulfenyl (or arylselenyl) chloride.
