Title of article
Microwave-enhanced solution coupling of the α,α-dialkyl amino acid, Aib
Author/Authors
Santagada، نويسنده , , Vincenzo and Fiorino، نويسنده , , Ferdinando and Perissutti، نويسنده , , Elisa and Severino، نويسنده , , Beatrice and De Filippis، نويسنده , , Vincenzo and Vivenzio، نويسنده , , Beniamino and Caliendo، نويسنده , , Giuseppe، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
5171
To page
5173
Abstract
The difficult coupling of α-aminoisobutyric acid (Aib), during the synthesis of dipeptides (1–6), was carried out using PyBOP/HOBt and HBTU/HOBt reagents by application of microwave energy in the presence of solvent. Room temperature, conventional heating (oil bath) and microwave irradiation of the reactions are compared. Synthesis by microwave irradiation gave the desired compounds in higher yields and in shorter reaction times than those obtained by conventional heating or at room temperature.
Keywords
difficult couplings , AIB , microwave irradiation in solution
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1646084
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