Design and synthesis of aryl/hetarylmethyl phosphonate-UMP derivatives as potential glucosyltransferase inhibitors

A novel class of glucosyltransferase inhibitors has been designed and synthesised. The designed inhibitors 1–4 provide conformational mimicry of the transition-state in glucosyltransfer reactions. The key synthetic steps involve a Michaelis–Arbuzov reaction followed by coupling with uridine-5′-morpholidophosphate as activated UMP derivative.