Author/Authors :
Terauchi، نويسنده , , Takeshi and Morita، نويسنده , , Masataka and Kimijima، نويسنده , , Kyoko and Nakamura، نويسنده , , Yasuhiro and Hayashi، نويسنده , , Gouichirou and Tanaka، نويسنده , , Taisaku and Kanoh، نويسنده , , Naoki and Nakata، نويسنده , , Masaya، نويسنده ,
Abstract :
The C29–C44 portion of altohyrtins (spongistatins) has been prepared from 1,5-pentanediol and d-glucose in a stereoselective manner. The convergent synthesis relied on a coupling reaction of the C29–C37 vinyl bromide and the C38–C44 Weinreb amide, diastereoselective reduction of the C38 ketone, and stereoselective formation of the C33–C37 (E ring) acetal.
Keywords :
altohyrtins , spongistatins , stereoselective synthesis , Weinreb coupling
