Author/Authors :
Qian، نويسنده , , Xuhong and Yao، نويسنده , , Wei and Chen، نويسنده , , Gang and Huang، نويسنده , , Xiayu and Mao، نويسنده , , Ping، نويسنده ,
Abstract :
A novel DNA photocleaver family of N-benzoyloxythioxonaphthalimides, which show improved DNA intercalation and photocleaving activity compared with their oxo- counterparts, were synthesized and evaluated. The substituents on the benzene ring of the benzoyloxy moiety have an important and unusual influence on the DNA photocleaving activity. N-(p-Methoxylbenzoyloxy)thioxonaphthalimide is able to photocleave DNA at low concentration (5 μM) with ‘time-resolved’ and pH independent properties.
