Author/Authors :
Simeone، نويسنده , , Joseph P and Bugianesi، نويسنده , , Robert L and Ponpipom، نويسنده , , Mitree M and Goulet، نويسنده , , Mark T and Levorse، نويسنده , , Mark S and Desai، نويسنده , , Ranjit C، نويسنده ,
Abstract :
The stereospecific formation of 2-aryl-β-methyl tryptamine derivatives 15 and 16 from chiral 4-chloro-1-(3,5-dimethylphenyl)-3-methylbutanones is described. These intermediates were further manipulated into the GnRH antagonists 1b and 1c in five steps.
