Author/Authors :
Tian، نويسنده , , Qingping and Nayyar، نويسنده , , Naresh K and Babu، نويسنده , , Srinivasan and Chen، نويسنده , , Lijian and Tao، نويسنده , , Junhua and Lee، نويسنده , , Steven and Tibbetts، نويسنده , , Anthony P. Moran، نويسنده , , Terence and Liou، نويسنده , , Jason and Guo، نويسنده , , Ming and Kennedy، نويسنده , , Timothy P، نويسنده ,
Abstract :
An efficient synthetic route to a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 has been developed employing a key asymmetric dianionic cyanomethylation of N-Boc-l-(+)-glutamic acid dimethyl ester. This methodology enables the preparation of this compound in kilogram quantities with an overall yield of 30%.
