Title of article :
1,3-Thiazino[6,5-b]indol-4-one derivatives. The first synthesis of indole phytoalexin cyclobrassinon
Author/Authors :
Such?، نويسنده , , Mojm??r and Kutschy، نويسنده , , Peter and Dzurilla، نويسنده , , Milan and Kov??ik، نويسنده , , Vladim??r and Andreani، نويسنده , , Aldo and Alf?ldi، نويسنده , , Juraj، نويسنده ,
Abstract :
The first synthesis of indole phytoalexin cyclobrassinon in six steps, in 12% overall yield and some of its analogues, possessing a 1,3-thiazino[6,5-b]indol-4-one tricyclic ring system was performed, starting from 2-chloroindole-3-carboxaldehyde and employing the intramolecular Et3N-mediated nucleophilic substitution of a chlorine atom in the 2-position of an indole ring with sulfur as a key step.
