Title of article
Direct C-3 lithiation of 1-(triisopropylsilyl)indole
Author/Authors
Yoshihiro Matsuzono، نويسنده , , Mai and Fukuda، نويسنده , , Tsutomu and Iwao، نويسنده , , Masatomo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
7621
To page
7623
Abstract
1-(Triisopropylsilyl)indole can be directly lithiated at 3-position with tert-BuLi-TMEDA in hexane at 0°C for 3 h. The generated lithio species is reacted with a variety of electrophiles to give 3-substituted 1-(triisopropylsilyl)indoles in good yields.
Keywords
indoles , lithiation , Substitution , regioselection
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1647903
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