Title of article :
Direct C-3 lithiation of 1-(triisopropylsilyl)indole
Author/Authors :
Yoshihiro Matsuzono، نويسنده , , Mai and Fukuda، نويسنده , , Tsutomu and Iwao، نويسنده , , Masatomo، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
1-(Triisopropylsilyl)indole can be directly lithiated at 3-position with tert-BuLi-TMEDA in hexane at 0°C for 3 h. The generated lithio species is reacted with a variety of electrophiles to give 3-substituted 1-(triisopropylsilyl)indoles in good yields.
Keywords :
indoles , lithiation , Substitution , regioselection
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
