Preparation of a resin-bound cyclic malonic ester and a facile solid-phase synthesis of 4(1H)quinolones

A resin-bound cyclic malonic ester has been prepared on Merrifield resin. Reaction of the cyclic malonic ester with triethyl orthoformate and subsequent substitution by an arylamine afforded arylaminomethylene cyclic malonic ester preloaded resin. A series of 4(1H)quinolones were prepared by thermal cyclization in moderate yields and high purity.