Pd-catalyzed asymmetric allylation with a novel C2-symmetric bisphosphinite ligand: 3R,3′R-bis(diphenylphosphinoxy)-6,6,6′,6′-tetramethyl-2S,2′S-di-4H-pyran

A novel C2-symmetric chiral bisphosphinite ligand, 3R,3′R-bis(diphenylphosphinoxy)-6,6,6′,6′-tetramethyl-2S,2′S-di-4H-pyran, was synthesized from d-mannitol and examined for palladium-catalyzed asymmetric allylic substitution. Under the optimized conditions, the allylation product can be obtained in up to 91.2% ee.