Title of article :
Synthesis of (3R*,4R*)-4-acetylamino-3-(pent-3-oxy)cyclohex-1-ene-1-carboxylic acid and its (3S*,4R*)-isomer and their inhibitory action against influenza virus sialidases
Author/Authors :
Kerrigan، نويسنده , , Sean A and Pritchard، نويسنده , , Robin A. J. Smith، نويسنده , , Paul W and Stoodley، نويسنده , , Richard J، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
(3R*,4R*)-4-Acetylamino-3-(pent-3-oxy)cyclohex-1-ene-1-carboxylic acid and its (3S*,4R*)-isomer are synthesised in five steps from the Diels–Alder cycloadduct of (E)-1-acetoxy-3-methylbuta-1,3-diene and nitroethene; the former acid is a moderately potent inhibitor of influenza A sialidase.
Keywords :
antivirals , oxidation (allylic) , Nitro compounds , Diels–Alder reactions
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
