Total synthesis of the marine sesquiterpene quinone (−)-cyclozonarone

The total synthesis of the naturally occurring sesquiterpene quinone (−)-cyclozonarone was achieved starting from (+)-albicanol. Elimination of water led to drima-(8,12),(9,11)-diene, which reacted in the key step of the synthesis—a Diels–Alder reaction—with benzoquinone. Further oxidation led to the target molecule.