Author/Authors :
Zouhiri، نويسنده , , Fatima and Desmaële، نويسنده , , Didier and dʹAngelo، نويسنده , , Jean and Ourevitch، نويسنده , , Michèle and Mouscadet، نويسنده , , Jean-François and Leh، نويسنده , , Hervé and Le Bret، نويسنده , , Marc، نويسنده ,
Abstract :
A novel variant of HIV-1 replication inhibitors of the styrylquinoline class, bearing an α-keto acid appendage at C-7, has been synthesized. Though completely inactive in in vitro experiments against HIV-1 integrase, this compound exhibited a significant antiviral activity (IC50=10 μM).
Keywords :
antivirals , Enzyme inhibitors , Quinolines , thioacetals , keto acids and derivatives
