Author/Authors :
Zhang، نويسنده , , Jinfang and Barker، نويسنده , , Julie and Lou، نويسنده , , Boliang and Saneii، نويسنده , , Hossain، نويسنده ,
Abstract :
A novel method for solid-phase synthesis of dihydroquinazoline derivatives is presented. Polymer-bound 4-bromomethyl-3-nitrobenzoate and the corresponding amide are utilized as versatile precursors that undergo nucleophilic displacement with amines followed by reduction and cyclocondensation reactions to afford structurally diverse dihydroquinazolines with excellent yield and purity.
