Title of article :
The first asymmetric synthesis of a dopamine D1 agonist, dihydrexidine, employing asymmetric conjugate addition technology
Author/Authors :
Asano، نويسنده , , Yasutomi and Yamashita، نويسنده , , Mitsuaki and Nagai، نويسنده , , Kazushige and Kuriyama، نويسنده , , Masami and Yamada، نويسنده , , Ken-ichi and Tomioka، نويسنده , , Kiyoshi، نويسنده ,
Abstract :
The first asymmetric synthesis of benzophenanthridine dopamine D1 full agonist, dihydrexidine, was accomplished employing three key processes, external chiral ligand-controlled conjugate addition of phenyllithium, Curtius conversion of a carboxylic group to an amino group, and finally Pictet–Spengler type cyclization completing skeleton construction.
