Author/Authors :
Zhang، نويسنده , , Hong-Jie and Tan، نويسنده , , Ghee Teng and Hoang، نويسنده , , Vu Dinh and Hung، نويسنده , , Nguyen Van and Cuong، نويسنده , , Nguyen Manh and Soejarto، نويسنده , , Djaja Doel and Pezzuto، نويسنده , , John M and Fong، نويسنده , , Harry H.S، نويسنده ,
Abstract :
We report herein the first isolation of a novel structural type sesquiterpene designated as ‘litseane’ from the twigs and leaves of Litsea verticillata Hance (Lauraceae). The isolate (litseaverticillol A, 1) was obtained as a racemate through bioassay-guided fractionation and found to inhibit the replication of human immunodeficiency virus (HIV) type 1 with an IC50 value of 5.0 μg/mL (21.4 μM) and a selectivity index of 2.6. Spectroscopic data and a potential biosynthetic pathway are given.
