Title of article
Harvesting short-lived hypoiodous acid for efficient diastereoselective iodohydroxylation in Crixivan® synthesis
Author/Authors
LeBlond، نويسنده , , Carl R and Rossen، نويسنده , , Kai and Gortsema، نويسنده , , Frank P and Zavialov، نويسنده , , Ilia A and Cianciosi، نويسنده , , Steven J and Andrews، نويسنده , , Arthur T and Sun، نويسنده , , Yongkui، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
8603
To page
8606
Abstract
The evasive hypoiodous acid is generated in situ from NaOCl and NaI and used efficiently for clean iodohydroxylation of 1, producing the Crixivan® intermediate 2 in high yield with highly efficient 1,3-asymmetric induction. This pH-tunable process allows HOI generation at a pH optimal for supressing byproduct formation in pH-sensitive iodohydroxylation reactions.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1648447
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