A novel approach towards the stereoselective synthesis of 2-azido-2-deoxy-β-d-mannosides

Low temperature mannosylation of glycosyl acceptors under the agency of S-(4-methoxyphenyl) benzenethiosulfinate (MPBT) and trifluoromethanesulfonic anhydride (Tf2O) with p-methoxyphenyl 2-azido-3-O-benzyl-4,6-O-benzylidene-2-deoxy-1-thio-α-d-mannopyranoside, readily available from d-mannosamine hydrochloride, affords 2-azido-2-deoxy-d-mannosides with high β-selectivity in good yields.