Title of article :
O-(7-Azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate–1-hydroxy-7-azabenzotriazole–copper(II) chloride: a promising epimerization-free segment coupling system for peptide synthesis
Author/Authors :
Nishiyama، نويسنده , , Yasuhiro and Ishizuka، نويسنده , , Sou and Kurita، نويسنده , , Keisuke، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
Simultaneous use of 1-hydroxy-7-azabenzotriazole and CuCl2 with O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate has been found to eliminate the enantiomerization of the carboxy-terminal amino acid residue in peptide synthesis by the segment condensation strategy.
Keywords :
1 , peptide synthesis , 3-tetramethyluronium hexafluorophosphate , Copper(II) chloride , epimerization suppressant , 1-hydroxy-7-azabenzotriazole , O-(7-azabenzotriazol-1-yl)-1 , 3
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
