Author/Authors :
Bartoli، نويسنده , , Giuseppe and Bosco، نويسنده , , Marcella and Dalpozzo، نويسنده , , Renato and Marcantoni، نويسنده , , Enrico and Massaccesi، نويسنده , , Massimo and Rinaldi، نويسنده , , Samuele and Sambri، نويسنده , , Letizia، نويسنده ,
Abstract :
In the presence of titanium tetrachloride, the borane/tetrahydrofuran complex can reduce 2-methyl-3-oxoamides into the corresponding syn-aminols in good yields and high diastereoselectivity. The use of borane/dimethyl sulfide instead of BH3/THF allows a partial reduction to syn-β-hydroxyamides.
Keywords :
Aminoalcohols , diastereoselection , hydroxy amides , Boranes , TiCl4
