Title of article
Formation of phostonic acids during the reduction of azidonucleosidephosphonic acids
Author/Authors
Morr، نويسنده , , Michael and Kakoschke، نويسنده , , Christel and Ernst، نويسنده , , Ludger، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
8841
To page
8843
Abstract
Reduction of 5′-azido-3′,5′-dideoxy-3′-(phosphorylmethyl)nucleosides, either with H2/Pd/C or with dithiothreitol, leads to cyclic phosphonate esters (phostonic acids) in addition to the desired 5′-amino compounds. The phostonic acids are obtained as the main products when a 20-fold excess of dithiothreitol is used.
Keywords
nucleosides , phosphonic acids and derivatives , cyclonucleotide analogs
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1648629
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