Title of article :
Synthesis of (4R*,5S*)-5-acetylamino-4-diethylcarbamoyl-5,6-dihydro-4H-pyran-2-carboxylic acid and its inhibitory action against influenza virus sialidases
Author/Authors :
Kerrigan، نويسنده , , Sean A and Pritchard، نويسنده , , Robin A. J. Smith، نويسنده , , Paul W and Stoodley، نويسنده , , Richard J، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
(4R*,5S*)-5-Acetylamino-4-diethylcarbamoyl-5,6-dihydro-4H-pyran-2-carboxylic acid has been synthesised from methyl (E)-4-diethylcarbamoyl-2-oxobut-3-enoate and 2-nitroethanol; the acid is a moderately active inhibitor of influenza A sialidase.
Keywords :
Pyrans , antivirals , Cyclisation , enones , Michael reactions , Nitro compounds
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
