Mono-6-(O-2,4,6-triisopropylbenzenesulfonyl)-γ-cyclodextrin, a novel intermediate for the synthesis of mono-functionalised γ-cyclodextrins

A reaction between γ-cyclodextrin (γ-CD) and 2,4,6-triisopropylbenzenesulfonyl chloride in pyridine gave mono-6-(O-2,4,6-triisopropylbenzenesulfonyl)-γ-cyclodextrin in good yield (∼69%) and high purity (>98%). In contrast to other sulfonylations of γ-CD, this reaction did not give di- or tri-substituted side products and is thus useful for preparing pure mono-substituted γ-CD derivatives.