Title of article
Direct asymmetric synthesis of oxazolines from olefins using a chiral nitridomanganese complex: a novel three-component coupling leading to chiral oxazolines
Author/Authors
Minakata، نويسنده , , Satoshi and Nishimura، نويسنده , , Masaaki and Takahashi، نويسنده , , Toru and Oderaotoshi، نويسنده , , Yoji and Komatsu، نويسنده , , Mitsuo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
9019
To page
9022
Abstract
A new synthetic method for chiral oxazolines has been developed by N1 unit transfer to olefins using a chiral nitridomanganese complex. When trans-disubstituted styrenes were treated with chiral complex 1 in the presence of an acid chloride, oxazolines were obtained with high enantioselectivities (up to 92% ee). Furthermore, the produced oxazolines could be easily converted into β-amino alcohols, which are ephedrine derivatives.
Keywords
asymmetric synthesis , Chiral oxazolines , nitridomanganese complex , olefins
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1648760
Link To Document