Title of article :
Total synthesis of marine diterpenoid stolonidiol
Author/Authors :
Miyaoka، نويسنده , , Hiroaki and Baba، نويسنده , , Tomohiro and Mitome، نويسنده , , Hidemichi and Yamada، نويسنده , , Yasuji، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
Marine dolabellane diterpenoid stolonidiol was synthesized from l-ascorbic acid. The method for this total synthesis involves formation of the bicyclo[2.2.1]heptane derivative using a diastereoselective sequential Michael reaction, formation of cyclopentane derivative by the retro-aldol reaction and construction of an 11-membered carbocyclic ring through the intramolecular Horner–Wadsworth–Emmons reaction.
Keywords :
Antitumor compounds , Marine metabolites , terpenes and terpenoids
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
