Title of article
An improved synthesis of the C15–C28 fragment of laulimalide
Author/Authors
Sivaramakrishnan، نويسنده , , A. and Nadolski، نويسنده , , Geoffry T. and McAlexander، نويسنده , , Ian A. and Davidson، نويسنده , , Bradley S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
213
To page
216
Abstract
The C15–C28 fragment of the paclitaxel-like antimicrotubule agent laulimalide has been synthesized in 12 linear steps from known epoxide 5, with an overall yield of 16%. The methyldihydropyran ring of the side chain was efficiently prepared using ring-closing olefin metathesis chemistry. The 19,20-diol stereochemistry originates in starting material 7 and the side chain was appended using a Kocienski-modified Julia coupling.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1649132
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