Author/Authors :
Tripathy، نويسنده , , Rabindranath and Learn، نويسنده , , Keith S and Reddy، نويسنده , , Dandu R and Iqbal، نويسنده , , Mohamed and Singh، نويسنده , , Jasbir and Mallamo، نويسنده , , John P، نويسنده ,
Abstract :
A modified core structure of indolo[2,3-a]carbazole template has been immobilized. EtMgBr was identified as a substrate compatible base providing solid-phase dianion formation. Depending upon the nature of the electrophile, the core structure has been selectively functionalized to generate a library of kinase inhibitors.