Reactivity of 1,1′-thiocarbonyldiimidazole with glycosides: a novel and efficient glycosidic activation

The synthesis of monoglycosyl imidazoles and 1,1′-di-O-glycosides is described by direct glycosylation process from reducing sugar in the presence of 1,1′-thiocarbonyldiimidazole. Novel anomeric groups as 1-O-(imidazolyl)thiocarbonyl and 1-O-(imidazolyl)carbonyl are presented as potent glycosidic activators.