6-Chloro-2,4-dinitrophenylhydrazine as a useful crystalline agent for the determination of absolute configuration

For the determination of absolute configuration, we designed and synthesized some hydrazines as crystalline auxiliaries having a heavy atom, and found that 6-chloro-2,4-dinitrophenylhydrazine is a useful crystalline agent for chiral carbonyl compounds. The absolute configurations of chiral hydrazones prepared from the hydrazine and chiral ketones were determined by X-ray crystallographic analysis.