Author/Authors :
Niu، نويسنده , , Xuemei and Li، نويسنده , , Shenghong and Zhao، نويسنده , , Qinshi and Lin، نويسنده , , Zhongwen and Sun، نويسنده , , Handong and Lu، نويسنده , , Yang and Wang، نويسنده , , Cheng and Zheng، نويسنده , , Qitai، نويسنده ,
Abstract :
Two novel 3,6-epoxy-6,7:8,15-seco-7,20-olide-ent-kaurane diterpenoids laxiflorin F (1) and laxiflorin G (2) have been isolated from the leaves of Isodon eriocalyx var. laxiflora. The structure elucidation of 1 and 2 was accomplished by spectroscopic methods including 2D NMR analysis. The relative stereochemistry of 1 was established by single crystal X-ray crystallography, which also confirmed the novel carbon skeleton of the new ent-kaurane diterpenoid. Both compounds were tested for their cytotoxicity toward human leukemia K562 cells.
