Title of article
Amine–boranes: effective reducing agents for the deracemisation of dl-amino acids using l-amino acid oxidase from Proteus myxofaciens
Author/Authors
Alexandre، نويسنده , , François-René and Pantaleone، نويسنده , , David P. and Taylor، نويسنده , , Paul P. and Fotheringham، نويسنده , , Ian G. and Ager، نويسنده , , David J. and Turner، نويسنده , , Nicholas J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
707
To page
710
Abstract
The deracemisation of dl-α-amino acids using l-amino acid oxidase from Proteus myxofaciens and amine-boranes as chemical reducing agents has been investigated. Amine-boranes were found to be of particular interest in terms of reactivity and chemoselectivity compared to sodium borohydride and cyanoborohydride. Starting from the racemate, a range of d-amino acids were obtained in yields of up to 90% and e.e. >99%.
Keywords
d-amino acid , l-amino acid oxidase , amine–borane , deracemisation
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1649490
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